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|miR-488-5p and its role in melanoma|In: Experimental and Molecular Pathology. ACADEMIC PRESS INC ELSEVIER SCIENCE: San Diego. ISSN 0014-4800; e-ISSN 1096-0945, meer
Melanoma microRNA Wnt/ß-catenin pathway
|Auteurs|| || Top |
- Arnold, J.
- Engelmann, J.C., meer
- Schneider, N.
- Bosserhoff, A.K.
- Kuphal, S.
Due to their ability to regulate dozens to hundreds of target genes simultaneously and, therefore, influence several oncogenic pathways at the same time, microRNAs are a fascinating research object in melanoma. MicroRNAs have been identified as regulators of tumor proliferation, invasion and metastasis in melanoma.More precisely, it has been published that dysregulation of miR-488 contibutes to the progression of several cancer entities. However, the biological functions of miR-488, in special miR-488-5p in melanoma, remain unclear.This study showed the involvement of miR-488-5p in Wnt/β-catenin pathway and the function as a tumor suppressor. Transfection of miR-488-5p mimic led to inhibition of proliferation, migration, anchorage independent growth and led to induction of apoptosis.These data indicated that miR-488-5p acts as a tumor suppressor and is lost during melanoma development. The loss of miR-488-5p was confirmed in vivo by in situ hybridization on melanoma tissue.