Total synthesis of the alleged structure of crenarchaeol enables structure revision
Holzheimer, M.; Sinninghe Damste, J.S.; Schouten, S.; Havenith, R.W.A.; Minnaard, A.J. (2021). Total synthesis of the alleged structure of crenarchaeol enables structure revision. Angew. Chem. 133(32): 17645-17654. https://doi.org/10.1002/ange.202105384
In: Angewandte Chemie. Wiley: Weinheim. ISSN 1433-7851; e-ISSN 1521-3773, meer
|   |
| Auteurs | | Top |
- Holzheimer, M.
- Sinninghe Damste, J.S., meer
- Schouten, S., meer
|
- Havenith, R.W.A.
- Minnaard, A.J.
|
|
| Abstract |
Crenarchaeol is a glycerol dialkyl glycerol tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane-spanning lipid is undoubtedly the structurally most sophisticated of all known archaeal lipids and an iconic molecule in organic geochemistry. The 66-membered macrocycle possesses a unique chemical structure featuring 22 mostly remote stereocenters, and a cyclohexane ring connected by a single bond to a cyclopentane ring. Herein we report the first total synthesis of the proposed structure of crenarchaeol. Comparison with natural crenarchaeol allowed us to propose a revised structure of crenarchaeol, wherein one of the 22 stereocenters is inverted. |
|
