nieuwe zoekopdracht
[ meld een fout in dit record ]mandje (0): toevoegen | toon Print deze pagina

Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Brook, C.E.; Boots, M.; Chandran, K.; Dobson, A.P.; Drosten, C.; Graham, A.L.; Grenfell, B.; Müller, M.A.; Ng, M.; Wang, L.-F.; van Leeuwen, A. (2020). Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence. eLIFE 9.

Bijhorende data:
In: eLIFE. eLife Sciences Publications: Cambridge. e-ISSN 2050-084X, meer
Peer reviewed article  

Beschikbaar in  Auteurs 

Auteurs  Top 
  • Brook, C.E.
  • Boots, M.
  • Chandran, K.
  • Dobson, A.P.
  • Drosten, C.
  • Graham, A.L.
  • Grenfell, B.
  • Müller, M.A.
  • Ng, M.
  • Wang, L.-F.
  • van Leeuwen, A., meer

    Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats’ virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity, which can facilitate the establishment of rapidly-propagating persistent infections within-host. Rapidly-transmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats.

Alle informatie in het Integrated Marine Information System (IMIS) valt onder het VLIZ Privacy beleid Top | Auteurs 
IMIS is ontwikkeld en wordt gehost door het VLIZ, voor meer informatie contacteer .