|Development and validation of an analytical method for detection of estrogens in water|Noppe, H.; De Wasch, K.; Poelmans, S.; Van Hoof, N.; Verslycke, T.; Janssen, C.R.; De Brabander, H. (2005). Development and validation of an analytical method for detection of estrogens in water. Anal. Bioanal. Chem. 382(1): 91-98. dx.doi.org/10.1007/s00216-005-3174-8
In: Analytical and Bioanalytical Chemistry. Springer: Heidelberg. ISSN 1618-2642; e-ISSN 1618-2650
Is gerelateerd aan: Noppe, H.; De Wasch, K.; Poelmans, S.; Van Hoof, N.; Verslycke, T.; Janssen, C.R.; De Brabander, H.
(2006). Development and validation of an analytical method for detection of estrogens in water, in
: Noppe, H. Analytiek van hormoon verstorende stoffen in milieumatrices = Analytics of endocrine disrupting chemicals in environmental matrices.
pp. 21-41, meer
|Project|| Top | Auteurs | Dataset |
- Endocrine disruption in the Scheldt Estuary: distribution, exposure and effects
|Auteurs|| || Top | Dataset |
- Noppe, H.
- De Wasch, K.
- Poelmans, S.
- Van Hoof, N.
- Verslycke, T.
- Janssen, C.R.
- De Brabander, H., correspondent
An analytical procedure enabling routine analysis of four environmental estrogens at concentrations below 1 ng L–1 in estuarine water samples has been developed and validated. The method includes extraction of water samples using solid-phase extraction discs and detection by gas chromatography (GC) with tandem mass spectrometry (MS–MS) in electron-impact (EI) mode. The targeted estrogens included 17 alpha- and 17 beta-estradiol (aE2, bE2), estrone (E1), and 17 alpha-ethinylestradiol (EE2), all known environmental endocrine disruptors. Method performance characteristics, for example trueness, recovery, calibration, precision, accuracy, limit of quantification (LOQ), and the stability of the compounds are presented for each of the selected estrogens. Application of the procedure to water samples from the Scheldt estuary (Belgium – The Netherlands), a polluted estuary with reported incidences of environmental endocrine disruption, revealed that E1 was detected most frequently at concentrations up to 7 ng L–1. aE2 was detected once only and concentrations of bE2 and EE2 were below the LOQ
- Chemische analyse van oestrogenen, organochloor en organostikstof pesticiden als mogelijke endocriene verstoorders in het Schelde-estuarium