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Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis
Peigneur, S.; Van Der Haegen, A.; Möller, C.; Waelkens, E.; Diego-García, E.; Marí, F.; Naudé, R.; Tytgat, J. (2013). Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (New York, NY : 1980) 41: 8-16. https://hdl.handle.net/10.1016/j.peptides.2012.07.002
In: Peptides. Elsevier: New York etc.. ISSN 0196-9781; e-ISSN 1873-5169
Peer reviewed article  

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Trefwoorden
    Conus Linnaeus, 1758 [WoRMS]; Conus natalis G. B. Sowerby II, 1858 [WoRMS]; Conus pictus Reeve, 1843 [WoRMS]
    Marien
Author keywords
    Conus pictus; Conus natalis; Cone snail; Conotoxin; A-, M-, O-superfamily

Auteurs  Top 
  • Peigneur, S.
  • Van Der Haegen, A.
  • Möller, C.
  • Waelkens, E.
  • Diego-García, E.
  • Marí, F.
  • Naudé, R.
  • Tytgat, J.

Abstract
    Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology system for their own biological purposes by producing venoms which contains a structural and functional diversity of neurotoxins. These neurotoxins or conotoxins are often small cysteine-rich peptides which have shown to be highly selective ligands for a wide range of ion channels and receptors. Local habitat conditions have constituted barriers preventing the spreading of Conus species occurring along the coast of South Africa. Due to their scarceness, these species remain, therefore, extremely poorly studied. In this work, the venoms of two South African cone snails, Conus pictus, a vermivorous snail and Conus natalis, a molluscivorous snail, have been characterized in depth. In total, 26 novel peptides were identified. Comparing the venoms of both snails, interesting differences were observed regarding venom composition and molecular characteristics of these components.

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