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Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labrax) from European coasts
Schnitzler, J.G.; Klaren, P.H.M.; Bouquegneau, J.-M.; Das, K. (2012). Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labrax) from European coasts. Chemosphere 87(9): 1009-1017. hdl.handle.net/10.1016/j.chemosphere.2011.11.039
In: Chemosphere. Elsevier: Oxford. ISSN 0045-6535; e-ISSN 1879-1298, meer
Peer reviewed article  

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Trefwoorden
    Dicentrarchus labrax (Linnaeus, 1758) [WoRMS]
    Marien
Author keywords
    Dicentrarchus labrax; Persistent organic contaminants; Thyroid hormone metabolism; Deiodination; Glucoronidation; Sulfatation

Auteurs  Top 
  • Schnitzler, J.G.
  • Klaren, P.H.M.
  • Bouquegneau, J.-M.
  • Das, K.

Abstract
    Thyroid functional status of wild fish in relation with the contamination of their environment deserves further investigation. We here applied a multi-level approach of thyroid function assessment in 87 wild sea bass collected near several estuaries: namely the Scheldt, the Seine, the Loire, the Charente and the Gironde. Thyroxine (T4) and triiodothyronine (T3) concentrations in muscle were analyzed by radioimmunoassay. The activity of hepatic enzymes involved in extrathyroidal pathways of thyroid hormone metabolism, viz. deiodination, glucuronidation and sulfatation were analyzed. Last, follicle diameter and epithelial cell heights were measured. We observed changes that are predicted to lead to an increased conversion of T4–T3 and lowered thyroid hormone excretion. The changes in the metabolic pathways of thyroid hormones can be interpreted as a pathway to maintain thyroid hormone homeostasis. From all compounds tested, the higher chlorinated PCBs seemed to be the most implicated in this perturbation.

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